Interrogation of multicellular tumor-immune interactions
Cancer often comprises a seemingly disorganized, complex network of cells and molecules. Nevertheless, conserved rules of engagement exist. Weare studying human cancer and engineered mouse models to discover such mechanisms, leveraging our expertise in high parameter immune profiling at single cell and subcellular resolution.
Leveraging immunobiological consequences of stereotactic radiation
Therapeutic radiation can be used to deliver highly biologically active energy to anywhere in the body with millimeter precision. We aim to discover conserved biological programs that respond to stereotactic ionizing radiation, with the goal of leveraging these mechanisms as therapeutic opportunities.
Engineering new tools for mechanistic and therapeutic discovery
Using synthetic molecular biology, we are engineering creative new ways to dissect cell interactions in cancer immunity, and to construct custom precision therapeutic modules.